In Mali, a number of nightclubs and discotheques offer either live (African original or cover versions) or recorded (largely Western) dance music. When in Mali, well-known Malian musicians such as Habib Koité, a popular singer/guitarist, and Toumani Diabaté, a kora player, perform their compositions locally on weekends in pleasant open-air clubs that serve food and beer/sodas. Note that concerts start at around midnight.
Bamako is a city that comes into its own after dark, and on weekends it's a party town. Clubs don't get going before midnight and close around 6 am. Bla Bla Bar (Route de Bla Bla, Hippodrome) is Mali's most sophisticated bar, and though regulars lament that it has lost something since being glassed in and blasted with air-con, it's still filled with the bold and the beautiful at weekends.
The Evasion Jazz Club can be pretty cool on Fridays and Saturdays. The Hippo d'Or (close to Hippodrome) is also a nice place for enjoying non-stop live music on Fridays and, even more, on Saturdays. Ibiza and Le Terrace (next door to Bla Bla Bar) are still the hippest places to dance and drink.
For some less seedy drinking establishments, try No Stress & Jet Set, which both have pool tables as well. On Rue 360 (ACI-2000), Éspace Bouna is an agreeable garden venue that sometimes hosts Toumani Diabaté, Djelimady Tounkara and the Super Rail Band.
There is also a big casino near the Hotel L'Amitie.